pixi's CLI mirrors Cargo / npm / uv. Most muscle memory transfers.
pixi init <dir> creates a project (pixi.toml + .gitignore). pixi add <pkg> adds a conda-forge package. pixi add --pypi <pkg> adds a PyPI package (resolved via uv). pixi add --feature dev <pkg> adds to a feature group (pixi's equivalent of dev deps). pixi remove <pkg> removes one.
pixi run <cmd> runs a command in the project's environment — no manual activation. pixi run python script.py, pixi run pytest, pixi run jupyter lab all just work. pixi shell opens an interactive shell with the env active.
pixi global install <tool> installs a CLI tool globally with isolated deps — replaces Homebrew for many CLI tools you'd otherwise install via brew. pixi global list shows them. pixi global remove <tool> uninstalls.
pixi list shows packages installed in this project. pixi tree shows the dependency tree. pixi search <name> finds packages.